|
B-Cell Lymphomas
|
0.050 |
Biomarker
|
group |
BEFREE |
When compared with normal HCMs, the expressions of p53-upregulated modulator of apoptosis (PUMA), phosphatase and tensin homolog (PTEN), B-cell lymphoma-2-associated X protein (Bax) and caspase 7 proteins was decreased in HCMs overexpressing miRNA-214 following H<sub>2</sub>O<sub>2</sub> induction, and the rate of apoptosis decreased by 63.64, 21.95, 46.67 and 50.05%, respectively. miRNA-214 was highly expressed in the sera of elderly patients with AMI, which may inhibit myocardial cell apoptosis by inhibiting the expression of miR-214 target genes including <i>PUMA, PTEN, Bax and caspase 7</i>.
|
31086597 |
2019 |
|
SCAPULOPERONEAL MYOPATHY, X-LINKED DOMINANT
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 7 selected, potentially functional single nucleotide polymorphisms (SNPs) located in the microRNA binding sites of the 3' untranslational region (UTR; 2 in CASP3, 1 in CASP6, and 4 in CASP7) and evaluated their associations first with risk of SCCHN in 1066 patients with SCCHN and 1074 cancer-free control subjects and then with SPM in 846 patients in the same non-Hispanic white study population.
|
23271051 |
2013 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 7 selected, potentially functional single nucleotide polymorphisms (SNPs) located in the microRNA binding sites of the 3' untranslational region (UTR; 2 in CASP3, 1 in CASP6, and 4 in CASP7) and evaluated their associations first with risk of SCCHN in 1066 patients with SCCHN and 1074 cancer-free control subjects and then with SPM in 846 patients in the same non-Hispanic white study population.
|
23271051 |
2013 |
|
Alzheimer Disease, Late Onset
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We discovered a likely loss-of-function small deletion variant in the caspase 7 (CASP7) gene associated with significantly reduced incidence of LOAD in carriers of the high-risk APOE ε4 allele.
|
27358062 |
2016 |
|
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Using adenoviral technology, we overexpressed the proapoptotic molecules pro-caspase-3, pro-caspase-7, and Bax to induce therapeutic apoptosis of prostate cancer cell lines growing in vitro and in vivo.
|
11196158 |
2001 |
|
Malignant neoplasm of prostate
|
0.040 |
Biomarker
|
disease |
BEFREE |
Using adenoviral technology, we overexpressed the proapoptotic molecules pro-caspase-3, pro-caspase-7, and Bax to induce therapeutic apoptosis of prostate cancer cell lines growing in vitro and in vivo.
|
11196158 |
2001 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using a tumor necrosis factor (TNF)-α-induced bone marrow (BM)-MSC injury model in vitro and a rat MI model in vivo, we showed in the current study that miR-23a was involved in TNF-α-induced BM-MSC apoptosis through regulating caspase-7 and that the injection of BM-MSCs overexpressing miR-23a could improve left ventricular (LV) function and reduce infarct size in the rat MI model.
|
24269648 |
2014 |
|
B-Cell Lymphomas
|
0.050 |
AlteredExpression
|
group |
BEFREE |
TUNEL assay revealed that resveratrol induced cell apoptosis by increasing HCC apoptosis rate from 3±0.78% to 16±1.12% with upregulation of B‑cell lymphoma (Bcl)‑2 associated X, apoptosis regulator and cleaved‑poly (ADP‑Ribose) polymerase 1 (PARP), and downregulation of Bcl‑2, caspase‑3, caspase‑7 and PARP.
|
28983625 |
2017 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TUNEL assay revealed that resveratrol induced cell apoptosis by increasing HCC apoptosis rate from 3±0.78% to 16±1.12% with upregulation of B‑cell lymphoma (Bcl)‑2 associated X, apoptosis regulator and cleaved‑poly (ADP‑Ribose) polymerase 1 (PARP), and downregulation of Bcl‑2, caspase‑3, caspase‑7 and PARP.
|
28983625 |
2017 |
|
Spinocerebellar Ataxia Type 7
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To determine whether caspase cleavage is a critical event in SCA7 disease pathogenesis, we generated transgenic mice expressing polyQ-expanded ataxin-7 with a second-site mutation (D266N) to prevent caspase-7 proteolysis.
|
25859008 |
2015 |
|
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Thus, adenoviral-mediated transfer of caspase-7 may offer a new effective approach for the treatment of prostate cancer.
|
9927051 |
1999 |
|
Malignant neoplasm of prostate
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, adenoviral-mediated transfer of caspase-7 may offer a new effective approach for the treatment of prostate cancer.
|
9927051 |
1999 |
|
Small cell carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs, CASP8: rs1045494 (C > T), PIK3R1: rs3756668 (A > G) and CASP7: rs4353229 (T > C), were associated with longer overall survival in LD-SCLC patients after chemoradiotherapy.
|
26988918 |
2016 |
|
Locally Recurrent Malignant Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC.
|
21755562 |
2011 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC.
|
21755562 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
This study provides evidence that genetic variations of CASP7 may modulate OS and PFS of patients with advanced NSCLC treated with platinum-based chemotherapy.
|
22441531 |
2012 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This is the first report on the CASPASE-7 gene mutations in human malignancies, and our data suggest that the inactivating mutations of the CASPASE-7 gene might lead to the loss of its apoptotic function and contribute to the pathogenesis of some human solid cancers.
|
12970753 |
2003 |
|
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
These results suggest that the mitochondrial pathway is involved in Fas-mediated apoptosis in prostatic carcinoma cell lines and that, in addition to caspase-7 and caspase-3, there are other factors that confer nuclear apoptotic activity.
|
10786680 |
2000 |
|
Malignant neoplasm of lung
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CASP7 polymorphisms contribute to the genetic susceptibility to lung cancer.
|
19058873 |
2009 |
|
Carcinoma of lung
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CASP7 polymorphisms contribute to the genetic susceptibility to lung cancer.
|
19058873 |
2009 |
|
Primary malignant neoplasm of lung
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CASP7 polymorphisms contribute to the genetic susceptibility to lung cancer.
|
19058873 |
2009 |
|
Ischemic stroke
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that the rs12415607 A allele induces lower levels of transcriptional activity and CASP7 mRNA, and thus is associated with a reduced risk of IS.
|
31819117 |
2019 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Therefore, we made a Human Genome Epidemiology review and meta-analysis to explore the association between polymorphisms of CASP-3 and CASP-7 genes and cancer risk.
|
23765963 |
2013 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Therefore, we made a Human Genome Epidemiology review and meta-analysis to explore the association between polymorphisms of CASP-3 and CASP-7 genes and cancer risk.
|
23765963 |
2013 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Therefore, Tα1-mCH3 more efficiently inhibited the growth of 4 T1 and B16F10 tumors than Tα1.
|
31220695 |
2019 |